24. Julia Roberts: The Blind Side
Just because Roberts recognized the opportunity of one film doesn’t mean she hasn’t suffered her fair share of missed roles. Three years after Pretty Woman, she turned down the part as Annie Reed in the hugely successful Sleepless in Seattle. She also passed on two recent roles taken over by Sandra Bullock, including the part of Leigh Anne Tuohy in The Blind Side. This role earned Bullock her first Best Actress win.
Image Source: Dan MacMedan, USA TODAY NETWORK