23. New Girl (2011-2018)
Admittedly, there should have been some skepticism that quirky Zooey Deschanel could hold her own as the star of a sitcom. Well, she pulled it off rather brilliantly. Her Jess was sweet, funny, upbeat and compassionate as the teacher with a heart of gold. However, the antics of roommates Nick (Jake Johnson), Schmidt (Max Greenfield) and Winston (Lamorne Morris) helped take the show to a special level and multiple Golden Globe and Emmy nominations.
Image Source: IMDb