RANKED: The 25 Most Unforgettable Episodes Of Grey’s Anatomy Of All-Time

23. “How to Save a Life” (Season 11, Episode 21)

You’re going to need a box (or seven boxes) of tissues for this episode. Derek is on his way to the airport and gets into a horrible car accident. He rushes to save the lives of those around him. After his patients have been taken to the hospital, he makes a U-turn to follow the ambulances when he is struck by a truck. He is brought to another hospital and cannot speak to tell the doctors that they are treating him all wrong. Derek dies and Meredith spends his last moments with him.

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22. “Freedom: Part 2” (Season 4, Episode 17)

There are two new clinical trial patients, Beth and Jeremy, who fell in love after they met at a support group. Derek and Meredith sneak them into a private room to make love for the first time, after Beth’s parents disapproved of her and Jeremy’s relationship. Jeremy dies later on the OR table. Meredith lays candles around the patch of land where their house will be, a way to show Derek that she will trust him.

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