22. Annie Wilkes (Misery)
In recent years, Hollywood veteran Kathy Bates has played dastardly villains in multiple seasons of American Horror Story. Based on her epic performance in Misery, we should have seen it coming. In Misery, Bates played the role of Annie Wilkes — a nurse and superfan of famous author Paul Sheldon (James Caan). While driving home one night following the completion of a new book, Sheldon crashes his car and is left in serious trouble…until Wilkes comes to the rescue.
Unfortunately, Wilkes’ true intentions — and psychotic personality — soon become apparent. The superfan holds Sheldon hostage and physically and mentally torments him. Oh, we also come to learn that she has previously murdered her father, a former roommate, and numerous hospital patients. Will Sheldon become her latest victim?
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