March Madness Predictions: Midwest Region

USA TODAY Sports, Brightcast Media

This is a fascinating region. Zach Edey and No. 1 Purdue are looking to avenge last year’s embarrassing Round of 64 loss to Farleigh Dickinson. If the Boilermakers are to make a run to Phoenix, they might have to knock off a Kansas team loaded with talent — albeit injured — a group of Volunteers that narrowly missed out on a No. 1 seed, and a talented Creighton team. Will one of those four advance to the Final Four or could a Cinderella crash the party?