March Madness Predictions: Midwest Region

(1) Purdue vs. (16) Montana St./Grambling

Matt Krohn-USA TODAY Sports

Last year, Purdue became the second No. 1 seed to lose to a No. 16. The Boilermakers lost to Farleigh Dickinson and have endured a year’s worth of doubt as a result. We still have some reservations about Purdue, but there is no way it will lose to another 16-seed.

Winner: Purdue