25. Virginia (2017-18)
These Cavaliers were the No. 1 overall seed heading into the 2018 NCAA Tournament. However, upstart Maryland, Baltimore County (UMBC) didn’t care. Virginia entered this 1 vs. 16 matchup with a 31-2 record and allowing an average of 54 points, but UMBC hit 12 3-pointers and shot 54.2 percent from the field to become the first team to score 70 or more points on the Cavaliers and win 74-54 for the NCAA Tournament’s greatest upset.
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